K. Mathwig, T. Albrecht, E. D. Goluch and L. Rassaei Challenges of Biomolecular Detection at the Nanoscale: Nanopores and Microelectrodes Analytical Chemistry 87 (2015) 5470.
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The interest in analytical devices, which typically rely on the reactivity of a biological component for specificity, is growing rapidly. In this Perspective, we highlight current challenges in all-electrical biosensing as these systems shrink towards the nanoscale and enable the detection of analytes at the single-molecule level. We focus on two sensing principles: nanopores and amperometric microelectrode devices.